Yuanpei Li, Ph.D. Assistant Professor
2700 Stockton Blvd
Oak Park Research Building
Suite 2405
Sacramento Campus
Ph: 916-734-4420
e-mail

The Nanomedicine and Biomaterials Laboratory aims to 1) develop next generation nano-medicine platforms, biomaterials and microfluidic devices by learning from nature and clinical practice, 2) obtain fundamental knowledge on how these subjects interact with biological systems, and 3) apply them to solve complex medical problems that are associated with cancer and other diseases. Our research projects integrate recent advances in interdisciplinary fields, such as nanotechnology, material sciences, chemistry, engineering and biology, to create innovative technologies and therapeutics. Significant efforts have also been devoted to the rapid “bench to bed side” translation of these innovative technologies and therapeutics that can tremendously benefit the health of human and companion animals. We are particularly interested in the following research area:

  1. Targeting and programmable drug/gene delivery
  2. Theranostics
  3. New biomaterials/bio-inspired materials
  4. Integration of nanotechnology/biomaterials in microfluidics
  5. Exosomes/ oncosomes and cancer stem cells from clinical cancer patients
  6. Enabling technology for immunoengineering

Wang Z, Qiao R, Tang N, Lu Z, Wang H, Zhang Z, Xue X, Huang Z, Zhang S, Zhang G, Li Y*(corresponding author), Active targeting theranostic iron oxide nanoparticles for MRI and magnetic resonance-guided focused ultrasound ablation of lung cancer. Biomaterials, 2017,127, 25–35

Luo Y, Feng C, Xiao K, Yang X, Liu Q, Lin T, Zhang H, Walton JH, Ajena Y, Hu Y, Lam KS, Li Y*(corresponding author), “One-Pot” Fabrication of Highly Versatile and Biocompatible Poly(vinyl alcohol)-porphyrin-based Nanotheranostics, Theranostics, 2017, In press

Xiao W, Suby N, Xiao K, Lin T, Al Awwad N, Lam KS, Li Y*(corresponding author), Extremely long tumor retention, multi-responsive boronate crosslinked micelles with superior therapeutic efficacy for ovarian cancer. Journal of Controlled Release, 2017, In press

Yang X, Luo Y, Lin T, Zhang H, Lac D, Xiao K, Lam KS, Li Y*(corresponding author), Sub-100 nm, Long Tumor Retention SN-38-Loaded Photonic Micelles for Tri-modal Cancer Therapy. Journal of Controlled Release, 2017, 261, 297-306

Xiao K, Lin T, Lam KS, Li Y*(corresponding author), A facile strategy for fine-tuning the stability and drug release of stimuli-responsive cross-linked micellar nanoparticles towards precision drug delivery. Nanoscale, 2017, 9, 7765 - 7770

Wang X, Kong D, Lin T, Li X, Izumiya Y, Ding X, Zhang L, Hu X, Yang J,  Gao S, Lam K, Li Y* (corresponding author), A versatile nanoplatform for synergistic combination therapy of esophageal cancer. Acta Pharmacologica Sinica, 2017, 38, 931–942

Hao D, Xiao W, Liu R, Kumar P, Li Y, Zhou P, Guo F, Farmer D, Lam KS, Wang F, Wang A, Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration, ACS Chemical Biology, 2017, 12 (4), 1075-1086

Zhou F, Shimoda M, Olney L, Lyu Y, Tran K, Jiang G, Nakano K, Davis RR, Tepper CG, Maverakis E, Campbell M, Li Y, Dandekar S & Izumiya Y, Oncolytic Reactivation of KSHV as a Therapeutic Approach for Primary Effusion Lymphoma, Molecular Cancer Therapeutics, 2017, Accepted

He W, Felderman M, Evans AC, Geng J, Homan D, Bourguet F, Fischer Li Y, Lam KS, Noy A, Xing L, Cheng HR, Rasley A, Blanchette CD, Kamrud K, Wang N, Gouvis H, Peterson TC, Hubby B, Coleman MA, Cell-free Production of a Functional Oligomeric Form of a Chlamydia Major Outer Membrane Protein (MOMP) for Vaccine Development, Journal of Biological Chemistry, 2017, In press

Bharadwaj G, Viet Nhan V, Yang S, Li X, Narayanan A, Macarenco AA, Shi Yu, Yang D, Vieira SL, Xiao W, Li Y & Lam KS, Cholic acid-based novel micellar nanoplatform for delivering FDA-approved taxanes, Nanomedicine (London), 2017, 12(10):1153-1164

Lin T, Guo W, Long Q, Ma A, Liu Q, Zhang H, Pan C, Lam KS, Li Y* (corresponding author). HSP90 inhibitor encapsulated photo-theranostic nanoparticles for synergistic combination cancer therapy. Theranostics, 2016, 6(9), 1324-1335

Lin T/Li Y (co-first author), Liu Q, Chen J, Zhang H, Lac D, Zhang H, Ferrara KW, Wachsmann-H S, Li T, Airhart S, deVere White R, Pan C, Lam KS, Novel theranostic nanoporphyrins for photodynamic diagnosis and trimodal therapy for bladder cancer. Biomaterials, 2016,104, 339-351

Bharadwaj G, Lee JS, Kekessie I, Lam KS, Li Y* (corresponding author). A facile and efficient approach for production of reversible disulfide cross-linked micelles. Journal of Visualized Experiments, 2016, In Press

Pan A, Zhang H, Li Y, Lin T, Wang F, Lee J, Cheng M, Dall’Era M, Li T, deVere White R, Pan C and Lam KS, Disulfide-crosslinked nanomicelles confer cancer-specific drug delivery and improve efficacy of paclitaxel in bladder cancer. Nanotechnology, 2016, 27, 425103

Orbay H, Li Y, Xiao W, Cherry SR, Lam KS, Sahar DE, Developing a Nanoparticle-Delivered High-Efficacy Treatment for Infantile Hemangiomas Using a Mouse Hemangioendothelioma Model. Plastic and Reconstructive Surgery, 2016, 138(2), 410-417

Xiao K/Li Y (co-first author), Wang C, Ahmad S, Vu M, Kuma K, Cheng Y, Lam KS, Disulfide cross-linked micelles of novel HDAC inhibitor thailandepsin A for the treatment of breast cancer. Biomaterials, 2015, 67,183-193, PMID: 26218744 

Lin T, Rodriguez CO, Li Y, Nanomedicine in Veterinary Oncology, The Veterinary Journal, 2015, 205 (2):189-197, PMID: 25862394

Zhang P, Zam A, Jian Y, Wang X, Li Y, Lam KS, Flannery JG, Burns ME, Sarunic MV, Pugh E, Zawadzki R, Compact, wide-field multispectral SLO-OCT in vivo mouse retinal imager: system design, performance and applications, Journal of Biomedical Optics, 2015, 20(12), 126005

Chen Y, Su J, Duan L, Li Y, Liu X, Preparation of waterborne polyurethane acrylate (PUA) and application to UV-curing coatings. Journal of Chemical Science and Technology, 2015; 4(1):8-15

Li Y* (corresponding author), Xiao K, Zhu W, Deng W, Lam KS*, Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers. Advanced Drug Delivery Reviews, 2014, 66, 58-73, PMID: 24060922

Li Y* , Lin T, Luo Y, Liu Q, Xiao W, Guo W, Lac D, Zhang H, Feng C, Wachsmann-H S, Walton JH, Cherry SR, Rowland DJ, Kukis D, Pan C, Lam KS*, A smart and versatile theranostic nanomedicine platform based on nanoporphyrin. Nature Communications, 2014, 5, 4712, PMID: 25158161, (reported as a Research Highlight by Nature Publishing Group (NPG))

Jian Z, Han H, Zhang T, Puglisi J, Izu LT, Shaw JA , Onofiok E, Erickson JR, Chen Y, Horvath B, Shimkunas R, Xiao W, Li Y, Pan T, Chan J, Banyasz T, Tardiff JC, Chiamvimonvat N, Bers DM, Lam KS & Chen-Izu Y, Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Science Signaling, 2014, 7, ra27, PMID: 24643800 (Featured as Cover Image)

Zhang H, Li Y, Lin T, Xiao K, Haddad AS, Henderson PT, Jonas BA, Chen M, Xiao W, Liu R, Lam KS, Pan C, Nanomicelle formulation modifies the pharmacokinetic profiles and cardiac toxicity of daunorubicin. Nanomedicine, 2014, 20, 1-14, PMID:24628688

Lin T, Li Y, Zhang H, Luo J, Goodwin N, Gao T, White R, Lam KS, Pan C, Tumor-targeting multifunctional micelles for imaging and chemotherapy of advanced bladder cancer. Nanomedicine, 2013, 8(8):1239-1251, PMID: 23199207

Guo W, Liu R, Bhardwaj G, Ma A, Changou C, Yang JC, Li Y, Feng C, Luo Y, Mazloom A, Sanchez E, Wang Y, Huang W, Patterson R, Evans CP, Lam KS, Kung HJ, CTA095, a Novel Etk and Src Dual Inhibitor, Induces Apoptosis in Prostate Cancer Cells and Overcomes Resistance to Src Inhibitors. PLoS One, 2013, 8(8), e70910, PMID: 23967135

Xiao K, Suby N, Li Y, Lam KS, Telodendrimer-based nanocarriers for the treatment of ovarian cancer. Therapeutic Delivery, 2013, 4 (10), 1279-1292, PMID: 24116912

Xiao W, Bononi FC, Townsend J, Li Y, Liu R, Lam KS, Immobilized OBOC combinatorial bead array to facilitate multiplicative screening. Comb Chem High Throughput Screen. 2013, 16: 441-448, PMCID: 23488896

Xiao K/Li Y (co-first author), Lee JS, Gonik AM, Dong T, Fung G, Sanchez E, Xing L, Cheng HR, Luo J, Lam KS, "OA02" Peptide facilitates the precise targeting of paclitaxel-loaded micellar nanoparticles to ovarian cancer in vivo. Cancer Research, 2012, 72(8):2100-2110, PMID:22396491

Li Y, Budamagunta M, Luo J, Xiao W, Voss J, Lam KS, Probing of the assembly Structure and dynamics within nanoparticles during interaction with blood proteins. ACS Nano, 2012, 6 (11), 9485-9495, PMID: 23106540 

Li Y, Xiao W, Xiao K, Berti L, Luo J, Tseng HP, Fung G and Lam KS, Well-defined, reversible boronate crosslinked nanocarriers for targeted drug delivery in response to pH and cis-Diols. Angewandte Chemie International Edition, 2012, 51, 2864-2869, PMID: 22253091 (Very Important Paper (VIP) (top 5%), highlighted on the inside back cover) 

Lin T, Zhang H, Luo J, Li Y, Gao T, Lara PN, White R, Lam KS, Pan C, Multifunctional targeting micelle nanocarriers with both imaging and therapeutic potential for bladder cancer. International journal of Nanomedicine, 2012, 7:2793-2804, PMID: 22745542

Kato J/Li Y (co-first author), Xiao K, Luo J, Lee JS, Toscano J, Lam KS, Reversibly disulfide cross-linked micelles for on-demand vincristine delivery. Molecular Pharmaceutics, 2012 9(6):1727-35, PMID: 22530955

Zhang H, Luo J, Li Y, Henderson PT, Wachsmann-Hogiu S, Lam KS, Pan C, Characterization of high affinity peptides and their feasibility for use in nanotherapeutics targeting leukemia stem cells. Nanomedicine: Nanotechnology, Biology and Medicine, 2012, 8(7):1116-1124, PMID: 22197725

Li Y, Xiao K, Luo J, Lee JS., Xiao W, Kato J, Lam KS, Well-defined, reversible disulfide cross-linked micelles for on-demand paclitaxel delivery. Biomaterials, 2011, 32 (27), 6633-6645, PMID: 21658763

Xiao K, Luo J, Li Y, Lee JS, Lam KS, PEG-oligocholic acid telodendrimer micelles for the targeted delivery of doxorubicin to B-cell lymphoma. Journal of Controlled Release, 2011,155(2), 272-281, PMID: 21787818

 

  • National Institutes of Health
  • Department of Defense
  • Xiangdong Xue (Postdoctoral scholar)
  • Hao Wu (Postdoctoral scholar)
  • Gaomai Yang (Postdoctoral scholar)
  • Zhao Ma (Postdoctoral scholar)
  • Yee Huang (Visiting graduate student)
  • Yixuan He (Visiting student)
  • Zhongyi (Johnny) Huang (Undergraduate)
  • Zicheng Zhao (Undergraduate)