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UC Davis Comprehensive Cancer Center

UC Davis Comprehensive Cancer Center

FEATURE | Posted Oct. 24, 2017

Stem cell recipient finally meets his match

Donor makes cross-Atlantic trek for emotional reunion

When Diana von der Heyde’s former classmate needed a stem cell transplant, she joined a bone marrow registry, never thinking she would one day save the life of a man more than 5,500 miles away — or that they would meet in person five years later.

Rick Little of Merced, Calif. was diagnosed with acute myeloid leukemia in 2011. Doctors referred him to UC Davis, where he learned he would need a stem cell transplant. Unaware of the donor’s identity, he was nevertheless grateful for the stranger’s selfless act.

After treatment to destroy cancer cells in his body and suppress his immune system, he received his transplant under the care of oncologists Carol Richman, Joseph Tuscano and Mehrdad Abedi. After a month in the hospital, the donor’s cells replaced the blood-forming system in his bone marrow, changing his red blood cell type from his original A-positive to his donor’s O-positive.

A tough recovery

Although Little hoped he and his donor might one day connect, their meeting almost never happened. Five months after the transplant, his blood counts had dropped and he had just 50 percent of his donor’s cells. Within a month, he had none — and relapsed. Doctors first gave him an additional course of anti-leukemia therapy which removed the abnormal cells. Then he received a donor leukocyte infusion using separately collected T cells from von der Heyde to stimulate the graft-versus-leukemia effect.

Little also developed a common side effect called graft-versus-host disease, or GVHD. The disease occurs when the donor's immune cells mistakenly attack the recipient’s normal cells. The problem can occur even when the patient is taking drugs to suppress the immune system, as Little was and continues to take today to combat GVHD. The transplant and immunosuppressive therapy worked.

Connected at last

Curious about his donor, Little supplied his contact information to the National Marrow Donation Program, hoping to hear from his “angel.” In February 2014 von der Heyde responded in an email from her home in Holzwickede, Germany.

Little’s spirit lifted. Their friendship was instant. They shared details about their families, exchanged photos. After months of emailing, they initiated weekly Skype chats on Sunday evenings.

“It lights me up,” Little said of his calls with von der Heyde. “I can’t get the smile off my face.”

An unforgettable meeting

In October — five years after Little’s transplant —von der Heyde flew to California with her boyfriend, Tim Mester, to meet Little, Little’s adult children and grandchildren and his medical team at UC Davis Health.

“It was unreal, like meeting a family member,” said von der Heyde, still surprised to have had such a lasting impact on someone and with so little effort. “It’s no big deal because it’s just like donating blood. It can have such a big effect.”

On a warm October morning, Little guided his visitors through the main hospital and Cancer Center, sharing stories of his treatments and reminiscing with staff. The recipient introduced his donor to his nurses and stem cell transplant team, who held back tears as they embraced them both.

“I truly love this woman,” he said after their reunion.

The two have agreed to meet again in five years—when Little is 75 and von der Heyde, 35. The age gap, language barrier and thousands of miles are only minor hurdles for these friends, who share much more than an O-positive blood type.