Janine LaSalle, Ph.D.
Our laboratory is interested in the role of epigenetics in human autism-spectrum disorders. Epigenetics is the study of heritable changes in chromosomes that are not encoded in the DNA sequence, including DNA methylation and chromatin organization. The clinical applications of our research include understanding the pathogenesis of the neurodevelopmental disorders autism, Rett syndrome, Prader-Willi syndrome, Angelman syndrome, and Dup15q syndrome. We are also interested in identifying epigenetic biomarkers at the interface of genetic and environmental risk factors in autism-spectrum disorders using tissues accessible from birth, such as placenta and cord blood.
Crary-Dooley FK, Tam ME, Dunaway KW, Hertz-Picciotto I, Schmidt RJ, LaSalle JM. A comparison of existing global DNA methylation assays to low-coverage whole genome bisulfite sequencing for epidemiology studies. Epigenetics. 2017; 12(3): 206–214.
Dunaway KW, Gorrha S, Malelski L, Urraca N, Lein PJ, Korf I, Reiter LT, LaSalle JM. Dental pulp stem cells model early life and imprinted DNA methylation patterns. Stem Cells. 2017 Apr;35(4):981-988.
Schroeder DI, Schmidt RJ, Crary FK, Walker CK, Ozonoff S, Tancredi DJ, Hertz-Picciotto I, LaSalle JM. Placental methylome analysis from a prospective autism study. Mol Autism, 2016 Dec 15;7:51.
Schmidt RJ, Schroeder DI, Crary FK, Barkoski JM, Tancredi DJ, Walker CK, Ozonoff S, Hertz-Picciotto I, LaSalle JM. Self-reported pregnancy exposures and placental DNA methylation in the MARBLES prospective autism sibling study. Environmental Epigenetics, 2016 Dec;2(4).
Dunaway KW, Islam MS, Coulson RL, Lopez SJ, Vogel Ciernia A, Chu RG, Yasui DH, Pessah IN, Lott P, Mordaunt C, Meguro-Horike M, Horike S, Korf I, LaSalle JM. Cumulative impact of polychlorinated biphenyl and large chromosomal duplications on DNA methylation, chromatin, and expression of autism genes. Cell Reports. 2016 Dec 13;17(11):3035-3048.
Medici V, Kieffer DA, Shibata NM, Chima H, Kim K, Canovas A, Medrano JF, Islas-Trejo AD, Kharbanda KK, Olson K, Su RJ, Islam MS, Syed R, Keen CL, Miller AY, Rutledge JC, Halsted CH, LaSalle JM. Wilson Disease: epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model. 64. Epigenetics. 2016 11(11):804-818. PMID: 27611852
Veeraragavan S, Wan Y-W, Connolly DR, Hamilton SM, Ward CS, Soriano S, Pitcher MR, McGraw CM, Huang SG, Green JR, Yuva LA, Liang AJ, Neul JL, Yasui DH, LaSalle JM, Liu Z, Paylor R, Samaco RC. 2016. Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome. Hum Mol Genet. Aug 1;25(15):3284-3302. PMID: 27365498
Vogel Ciernia A, LaSalle JM. 2016. The landscape of DNA methylation amid a perfect storm of autism aetiologies. Nature Reviews Neuroscience, 17:411-23.
Rube HT, Lee W, Hejna M, Chen H, Yasui DH, LaSalle JM, Song JS, Gong Q. 2016. Sequence features accurately predict genome-wide MeCP2 binding in vivo. Nature Communications, 7:11025.
Crawley JN, Heyer WD, LaSalle JM. 2016. Autism and cancer share risk genes, pathways and drug targets. Trends in Genetics. 32:139-146. 32:139-46.
Schroeder DI, Jayashankar K, Douglas KC, Thirkill TL, York D, Dickinson PJ, Williams LE, Samollow PB, Ross PJ, Bannasch DL, Douglas GC, LaSalle JM. 2015. Early developmental and evolutionary origins of gene body DNA methylation patterns in mammalian placentas. PLOS Genet. 11(8):e1005442.
LaSalle JM, Reiter LT, Chamberlain SJ. 2015. Epigenetic regulation of UBE3A and roles in human neurodevelopmental disorders. Epigenomics. 7:1213-28.
Powell WT and LaSalle JM. 2015. Epigenetic mechanisms in diurnal cycles of metabolism and neurodevelopment. Hum. Mol. Genet. 24(R1):R1-9