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Department of Neurology

Department of Neurology

Faculty | Professors


Lab: Pleasure Lab 


Multiple sclerosis 


Astrocyte biology 


Feature Stories:

White Matter Matters: UC Davis neurology researchers focus on brain’s superhighway of connectors 




To see if David Pleasure is accepting new patients, or for assistance finding a UC Davis doctor, please call (800) 2-UC DAVIS.

David Pleasure, M.D.

David Pleasure, M.D.

Professor of Neurology and Pediatrics
Director of Research, Shriner's Hospital for Children
Director, Institute for Pediatric Regenerative Medicine
Distinguished Professor, UC Davis
Specialty: Neurology

Neurology Research, Shriner’s Hospital
2425 Stockton Blvd.
Sacramento, CA  95817

Clinical & Research Interests

David Pleasure studies how inflammation of white matter contributes to certain autoimmune diseases like multiple sclerosis, cerebral palsy and several inherited childhood diseases such as adrenoleukodystrophy. He also focuses on periventricular leukomalacia (PVL) – a disorder of developing white matter in premature infants – that frequently results in cerebral palsy. Pleasure’s studies on immature oligodendroglia – cells that make myelin – contributed significantly to the understanding of both disorders.


P&S, Columbia
New York, New York
M.D. 1963


Yale College
New Haven, Connecticut
B.A. 1959


Neurological Institute, Columbia
New York, New York  


NINDS, National Institute of Health
Bethesda, Maryland

Select Recent Publications

Itoh (T), Horiuchi, Ikeda, Xu, Bannerman, Pleasure, Penninger, Tournier, Itoh (A) (2014) ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. J Neurosci 34:10729-10742.

Moreno, Bannerman, Ma, Guo, Miers, Soulika*, Pleasure* (2014) Conditional deletion of astroglial CCL2 suppresses CNS accumulation of M1 macrophages and preserves axons in mice with MOG peptide EAE. J Neurosci 34:8175-8185 (PMID: 24920622). *co-senior authors

Chetty, Friedman, Kirby, Mirescu, Taravosh-Lahn, Guo, Krupik, Nicholas, Geraghty, Krishnamurthy, Tsai, Covarrubias, Wong, Francis, Sapolsky, Palmer, Pleasure, Kaufer (2014) Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus. Mol Psychiatry, in press (PMID: 24514565).

Burns, Miers, Xu, Man, Moreno, Pleasure, Bannerman (2014) Neuronopathy in the motor cortex in a chronic model of multiple sclerosis. J Neuropathol Exp Neurol 73:335-344 (PMID: 24607968).

Gan, Lee, Suzuki, Yamagami, Stokes, Nguyen, Pleasure, Zhou (2014) Pax6 mediates -catenin signaling for self-renewal and neurogenesis by radial glia-derived neural stem cells. Stem Cells 32:45-58 (PMID: 24115331).

Jiang, Chen, Wang, Chechneva, Chung, Rao, Pleasure, Liu, Zhang, Deng (2013) hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury. Nature Commun 4:2196 (PMID: 23880652).

Lang, Maeda, Bannerman, Jie, Xu, Horiuchi, Pleasure*, Guo* (2013) Adenomatous polyposis coli regulates oligodendroglial differentiation. J Neurosci 33:3113-3130 (PMID: 23407966). *co-senior authors.

Sohn, Selvaraj, Wakayama, Orosco, Lee, Guo, Horiuchi, Zarbalis, Itoh, Deng, Pleasure (2012) PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum. J Neurosci 32:12152-12164 (PMID: 22933798).

Guo, Maeda, Mills Ko, Delgado, Horiuchi, Soulika, Miers, Burns, Itoh, Shen, Lee, Sohn, Pleasure (2012) Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to EAE or their normal development. J Neurosci 32:639-645 (PMID: 22238099).

Guo, Maeda, Ma, Delgado, Sohn, Miers, Mills Ko, Bannerman, Xu, Wang, Zhou, Takebayashi, Pleasure (2011) Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis. J Neurosci 31:11914-11928 (PMID: 21849552).

Itoh, Horiuchi, Wakayama, Xu, Bannerman, Pleasure, Itoh (2011) ZPK/DLK, a mitogen-activated protein kinase kinase kinase, is a critical mediator of programmed cell death of motoneurons. J Neurosci 31:7223-7228 (PMID: 21593306).

Guo, Maeda, Ma, Xu, Miers, Vaccarino, Pleasure (2010) Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex. J Neurosci 30:12036-12049 (PMID: 20826667).

Soulika, Lee, McCauley, Miers, Bannerman, Pleasure (2009) Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis. J Neurosci 29:14965-14979 (PMID: 19940192).

Guo, Ma, McCauley, Pleasure (2009) Early postnatal plp-promoter expressing progenitors produce multilineage cells during normal in vivo development. J Neurosci 29:7256-7270 (PMID: 19494148).

Bannerman, Horiuchi, Feldman, Hahn, Ito, See, Jia, Itoh, Pleasure (2007) GluR2-free AMPA receptors intensify demyelination in EAE. J Neurochem 102:1064-1070 (PMID: 17472701).

Bannerman, Hahn, Ramirez, Bonnemann, Yu, Rostami, Pleasure (2005) Motor neuron pathology in thy1-YFP transgenic mice with experimental autoimmune encephalomyelitis. Brain 128:1877-1886, 2005 (PMID: 15901645).