Mary Jacena S. Leigh, M.D.
Pediatric Child Development & Behavior
- Associate Physician Diplomate
- Assistant Clinical Professor
Dr. Leigh is interested in general child development, both typical and atypical, as well as in neurodevelopmental disorders including autism spectrum disorder and attention deficit hyperactivity disorder.
She is also interested in developmental evaluations for infants and toddlers who are at high risk for developmental delays.
Dr. Leigh is involved in research aimed at developing targeted treatments for genetic and neurodevelopmental disorders. She is currently a clinician in clinical trials and research studies for fragile X syndrome and autism spectrum disorder.
Child Development and Behavior
M.D., Geffen School of Medicine-UCLA, Los Angeles CA 2006
B.A., UC Berkeley, Berkeley CA 2011
Pediatrics, UC Davis Medical Center, Sacramento CA 2007-2009
Developmental and Behavioral Pediatrics, UC Davis MIND Institute, Sacramento CA 2009-2012
American Board of Pediatrics, Developmental and Behavioral,
American Board of Pediatrics, General Pediatrics,
International Society for Autism Research
Phi Beta Kappa Honor Society
Society for Developmental and Behavioral Pediatrics
Society for the Scientific Study of Behavioral Phenotypes
Western Society for Pediatric Research
Honors and Awards
Conquer Fragile X Young Investigator Award, National Fragile X Foundation, 2012
Annual Meeting Travel Award, Pediatric Academic Society, 2012
Research and Abbott Nutrition, 2012
Jeanne Spurlock Clinical Fellowship, American Academy of Child and Adolescent, 2003
I.L. Chaikoff Memorial Award for Outstanding Achievement and Excellence in Molecular & Cell Biology/ Cell & Developmental Biology, University of California Berkeley, 2001
Select Recent Publications
Schneider A, Leigh MJ, Adams P, Nanakul R, Chechi T, Olichney J, Hagerman RJ, Hessl D. Electrocortical Changes Associated with Minocycline Treatment in Fragile X Syndrome. J Psychopharmacol. 2013 Oct;27(10):956-63. Epub 2013 Aug 27.
Dziembowska M, Pretto DI, Janusz A, Kaczmarek L, Leigh MJ, Gabriel N, Durbin-Johnson B, Hagerman RJ, Tassone F. High MMP-9 activity levels in fragile X syndrome are lowered by minocycline. Am J Med Genet A. 2013 Aug;161A(8):1897-903. Epub 2013 Jul 3.
Leigh MJ, Nguyen DV, Mu Y, Winarni TI, Schneider A, Chechi T, Polussa J, Doucet P, Tassone F, Rivera SM, Hessl D, Hagerman RJ. A randomized double-blind, placebo-controlled trial of minocycline in children and adolescents with fragile x syndrome. J Dev Behav Pediatr. 2013 Apr;34(3):147-55.
Gianoukakis AG, Leigh MJ, Richards P, Christenson PD, Hakimian A, Fu P, Niihara Y, Smith TJ. Characterization of the anemia associated with Graves' disease. Clinical Endocrinology. 2009 May;70(5):781-7.
Machen TE, Leigh MJ, Taylor C, Kimura T, Asano S, Moore HP. pH of TGN and recycling endosomes of H+/K+-ATPase-transfected HEK-293 cells: implications for pH regulation in the secretory pathway. Am J of Physiology- Cell Physiology. 2003 Jul;285 (1):C205-14.
Leigh MJ, Partington L, Weeber E. Angelman Syndrome In Treatment of Neurodevelopmental Disorders- Targeting Neurobiological Mechanisms, eds. B Moghaddam, R Hagerman, and R Hendren, Oxford: Elsevier. 2014.
Leigh MJ, Hagerman RJ, Hessl, DR. Fragile X. In Clinical Manual of Neurodevelopmental Disorders, eds. S. Rogers and R. Hansen, Arlington: American Psychiatric Publishing. 2012.
Hendrickson DJ, Knisely AS, Coulter K, Telander DG, Quan R, Ruebner BH, Leigh MJ. An inborn error of bile salt transport with features mimicking abusive head trauma. Child Abuse & Neglect. 2010 Jun 1.